How was the National Mesothelioma Virtual Bank Developed?
National Institute of Occupational Health and Safety of the Centers for Disease Control and Prevention funds the National Mesothelioma Virtual Bank to provide mesothelioma tissue samples with clinical annotation to researchers. This is a model-driven bioinformatics system that integrates multimodal datasets into one architecture supported by a set of Common Data Elements with their attributes in order to facilitate basic science, clinical as well translational research. The NMVB data warehouse system is based on the Clinical Annotation Engine (CAE) suite of Cancer Biomedical Informatics Grid network developed by the Department of Biomedical Informatics at the University of Pittsburgh School of Medicine. It has various components such as data annotation and query engine, tools for image storage and analysis, and a data-warehouse for genomic and proteomics data sets. In addition to working to create a state-of-the-art bioinformatics platform, the NMVB team wanted to optimize the usefulness of the resource for the mesothelioma research community. To achieve this goal, the NMVB solicited input from mesothelioma researchers with a customized survey. The results of this survey influenced the type of specimens and related annotation included in the NMVB. If you have suggestions on how to further improve the NMVB, please contact us.