Individuals carrying a germline BAP1 mutation are at increased risk of developing mesothelioma. In mice, there is limited information and controversy regarding whether germline Bap1 heterozygous mutations alone cause mesothelioma, despite these mice being highly susceptible to even minimal asbestos exposure. To address this issue, we evaluated spontaneous mesothelioma development over the lifetime of a large cohort of Bap1-mutant mice and non-mutant, wild-type littermates across several genetic backgrounds.
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