TMAs

TMA 1

TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 40 patients have been incorporated: 36 patients have tissue cores from the primary lesion only, 3 patients have tissue cores from a metastatic lesion only, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 97% are male and 3% are female, and racial breakdown is as follows: 57% white, 3% black, and 39% unknown. Pathologic site and histologic type for annotated cases is shown.

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Histologic Type Cases
Biphasic 10
Epithelial/Epitheliod 20
Sarcomatoid 3
Multicystic 1
Papillary 2
Benign Fibrous 2
Fibrocystic 1
Desmoplastic 1
Benign 4
Malignant 36
Primary 36
Metastatic 3
Primary/Metastatic 1
Pathologic Site Cases
Pleura Not Specified 25
Peritoneum 13
Other 2
Supporting Documents
University of Pittsburgh TMA-1 Map: Map
University of Pittsburgh TMA-1 Whole Slide Image: Whole Slide Image

University of Pennsylvania

TMA 1

The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 10 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, 5 patients have tissue cores from the primary lesion and normal tissue, and 1 patient has tissue cores from the normal tissue, primary and metastatic lesions. Of the patients with available clinical annotation, 60% are male and 40% are female, and racial breakdown is as follows: 100% white.

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Histologic Type Cases
Epithelial/Epitheliod 90%
Sarcomatoid 10%
Pathologic Site Cases
Pleura Right 50%
Pleura Left 35.7%
Pleura 80%
Pleura Not Specified 12.5%
Other 20%
Supporting Documents
University of Pennsylvania TMA-1 Map Microsoft Excel file: Map
University of Pennsylvania TMA-1 Whole Slide Image: Whole Slide Image
TMA 2

The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 12 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, 2 patient has tissue cores from normal tissue only, 4 patients have tissue cores from the primary lesion and normal tissue, 1 patient has tissue cores from normal tissue, primary and metastatic lesions, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 91.6% are male and 8.3% are female, and racial breakdown is as follows: 100% white.

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Histologic Type Cases
Biphasic 33.3%
Epithelial/Epitheliod 50%
Sarcomatoid 16.6%
Pathologic Site Cases
Peritoneum 8.3%
Pleura 91.6%
Pleura Right 63.3%
Pleura Left 9.09%
Pleura Not Specified 27.7%
Supporting Documents
University of Pennsylvania TMA-2 Map Microsoft Excel file: Map
University of Pennsylvania TMA-2 Whole Slide Image: Whole Slide Image
TMA 3

The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 9 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, and 5 patients have tissue cores from normal tissue and primary lesions. Of the patients with available clinical annotation, 88.8% are male and 11.1% are female, and racial breakdown is as follows: 88.8% white, and 11.1% black.

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Histologic Type Cases
Biphasic 11.1%
Epithelial/Epitheliod 77.7%
Other (extrapleural/extra peritoneal) 11.1%
Pathologic Site Cases
Peritoneum 11.1%
Pleura 77.7%
Pleura Right 57.1%
Pleura Left 28.5%
Pleura Not Specified 14.2%
Other 11.1%
Supporting Documents
University of Pennsylvania TMA-3 Map Microsoft Excel file: Map
University of Pennsylvania TMA-3 Whole Slide Image: Whole Slide Image
TMA 4

The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 30 patients have been incorporated: 15 patients have tissue cores from the primary lesion only, 7 patients have tissue cores from normal tissue only, 1 patient has tissue cores from the metastatic lesion only, 6 patients have tissue cores from normal tissue and primary lesions, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 83.3% are male and 16.6% are female, and racial breakdown is as follows: 86.6% white, 3.3% black, and 10% unknown. Pathologic site and histologic type for annotated cases is below:

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Histologic Type Cases
Biphasic 13.3%
Epithelial/Epitheliod 73.3%
Sarcomatoid 13.3%
Pathologic Site Cases
Peritoneum 10%
Pleura 90%
Pleura Right 48.1%
Pleura Left 22.2%
Pleura Not Specified 22.9%
Supporting Documents
University of Pennsylvania TMA-4 Map Microsoft Excel file: Map
University of Pennsylvania TMA-4 Whole Slide Image: Whole Slide Image

Roswell Park Cancer Institute

TMA 1

TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 56 patients have been incorporated: 51 patients have tissue cores from the primary lesion only, 2 patients have tissue cores from a metastatic lesion only, 1 patient has tissue cores from both the primary and recurrent lesions, and 2 patients have cores from a recurrent lesion. Of the patients with available clinical annotation, 73.2 % are male and 26.8 % are female, and racial breakdown is as follows: 94.64 % white, 1.75 % black, 1.75% American Indian, and 1.75% Asian.

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Histologic Type Cases
Biphasic 11
Epithelial/Epitheliod 33
Sarcomatoid 3
Multicystic 1
Papillary 1
Not Specified 8
Malignant 57
Primary 52
Recurrent 3
Metastatic 2
Pathologic Site Cases
Pleura 40
Peritoneum 15
Other 2
Supporting Documents
Roswell Park Cancer Institute Map: Map

New York University Langone Medical Center (NYULMC)

TMA NYULMC

TMA 1

The TMA has been designed to facilitate identification of markers differentially expressed in primary and metastatic mesothelioma lesions. Samples from 66 patients have been incorporated: (132 cores). Of the patients with available clinical annotation, 66.2% are male and 33.8% are female, and a racial breakdown is as follows: 92.6% Caucasian, 2.9% Asian, 4.4% Other Race. Pathologic site and histologic type for the annotated cases has been listed below:

 

 

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Histologic Type Cases
Biphasic 22.1%
Desmoplastic 1.4%
Epithelial/Epitheliod 66.2%
Multicystic 1.4%
Sarcomatoid 8.8%
Pathologic Site Cases
Pleura 83.8%
Other 7.4%
Not Specified 4.4%
Pericardium 1.5%
Lung 1.5%
Metastasis 1.4%
Supporting Documents
NYULMC TMA Map file: Map

University of Maryland

University of Maryland School of Medicine

TMA

This TMA is comprised of 104 retrospective peritoneal malignant mesothelioma cases and turmor cores from patients with 91% of surgical resection performed at the University of Maryland Medical Center (UMMC) from 2006-2016.The predominant histological type is epithelial or epithelioid in 93% of cases. There are positive history of smoking in 31% of cases and history of asbestos exposure in 29 % of cases. All cases were reviewed microscopically by pathologists and tissue cores were selected based on variation in histologic type, nucleolar grade, level of invasion, and degree of inflammation. A code was assigned to each core at the time of microscopic review using the latest histologic evaluation standards. Two TMA’s were ultimately prepared to include all cases with sufficient size core extraction. The TMA’s will be stored in the Pathology Biorepository Shared Service (PBSS) core facility at the University of Maryland School of Medicine (UMB) for future requests made by the NMVB team.

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Supporting Documents
TMA A: Map
TMA B: Map